Molecular aspects of the epidemiology of virus disease
Identifieur interne : 002319 ( Main/Exploration ); précédent : 002318; suivant : 002320Molecular aspects of the epidemiology of virus disease
Auteurs : C. Scholtissek [Allemagne]Source :
- Experientia [ 0014-4754 ] ; 1987-12-01.
English descriptors
- KwdEn :
- Teeft :
- Antigenic, Antigenic drift, Antigenic shift, Archs virol, Avian influenza viruses, Chick, Chick embryo cells, Conformational change, Different cells, Different influenza, Double infection, Embryo, External trypsin, Foregoing strain, Fowl, Fowl plague, Fowl plague virus, Gene constellation, Genes coding, Genome, Hela cells, Hemagglutinin, Hong kong virus, Host cell, Host range, Human strains, Hybridization technique, Immune response, Influenza, Influenza virus, Influenza virus reservoir, Influenza viruses, Lake water, Large reservoir, Large reservoirs, Mdck cells, Molecular epidemiology, Monoclonal antibodies, Natural conditions, Neurotropic, Neurotropic reassortants, Neutralizing antibodies, Nucleoprotein, Other genes, Other viruses, Particular structure, Pathogenic, Phosphopeptide fingerprints, Reassortants, Reassortment, Reviews experientia, Scholtissek, Segmented structure, Species barrier, Such viruses, Surface antigens, Surface glycoproteins, Test tube, Various influenza, Virology, Virus, Virus particles, Virus strains, Virus titer, Water fowls.
Abstract
Summary: With regard to molecular epidemiology, influenza A viruses belong to the best-studied virus systems. At least two large reservoirs of influenza A viruses have been built up in nature, one in humans and another one in water fowls. The latter one is very heterogenous, consisting of viruses belonging to 13 hemagglutinin (HA) and 9 neuraminidase (NA) subtypes in almost all possible combinations. The segmented structure of the influenza virus genome allows the creation of new influenza strains by reassortment. By replacement of the HA gene of human strains new pandemic viruses can be generated (antigenic shift). The particular structure of the HA enables the human influenza A-viruses to create variants which can escape the immune response of the host (antigenic drift). The nucleoprotein is responsible for keeping those two large reservoirs apart. Mixing of genes of viruses from these two reservoirs seems to happen predominantly by double infection of pigs, which apparently are tolerant for infection by either human or avian influenza viruses. The molecular mechanisms described for influenza viruses can be explained by the particular structure of their genome and their components and cannot be generalized. Each virus has developed its own strategy to multiply and to spread.
Url:
DOI: 10.1007/BF01945523
Affiliations:
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Scholtissek</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institut für Virologie, Justus-Liebig-Universität Giessen, Franfurter Strasse 107, D-6300, Giessen</wicri:regionArea><wicri:noRegion>Giessen</wicri:noRegion><wicri:noRegion>Giessen</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Experientia</title><title level="j" type="abbrev">Experientia</title><idno type="ISSN">0014-4754</idno><idno type="eISSN">1420-9071</idno><imprint><publisher>Birkhäuser-Verlag</publisher><pubPlace>Basel</pubPlace><date type="published" when="1987-12-01">1987-12-01</date><biblScope unit="volume">43</biblScope><biblScope unit="issue">11-12</biblScope><biblScope unit="page" from="1197">1197</biblScope><biblScope unit="page" to="1201">1201</biblScope></imprint><idno type="ISSN">0014-4754</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0014-4754</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Epidemiology of influenza</term><term>antigenic drift</term><term>antigenic shift</term><term>reassortment</term><term>virus reservoirs</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Antigenic</term><term>Antigenic drift</term><term>Antigenic shift</term><term>Archs virol</term><term>Avian influenza viruses</term><term>Chick</term><term>Chick embryo cells</term><term>Conformational change</term><term>Different cells</term><term>Different influenza</term><term>Double infection</term><term>Embryo</term><term>External trypsin</term><term>Foregoing strain</term><term>Fowl</term><term>Fowl plague</term><term>Fowl plague virus</term><term>Gene constellation</term><term>Genes coding</term><term>Genome</term><term>Hela cells</term><term>Hemagglutinin</term><term>Hong kong virus</term><term>Host cell</term><term>Host range</term><term>Human strains</term><term>Hybridization technique</term><term>Immune response</term><term>Influenza</term><term>Influenza virus</term><term>Influenza virus reservoir</term><term>Influenza viruses</term><term>Lake water</term><term>Large reservoir</term><term>Large reservoirs</term><term>Mdck cells</term><term>Molecular epidemiology</term><term>Monoclonal antibodies</term><term>Natural conditions</term><term>Neurotropic</term><term>Neurotropic reassortants</term><term>Neutralizing antibodies</term><term>Nucleoprotein</term><term>Other genes</term><term>Other viruses</term><term>Particular structure</term><term>Pathogenic</term><term>Phosphopeptide fingerprints</term><term>Reassortants</term><term>Reassortment</term><term>Reviews experientia</term><term>Scholtissek</term><term>Segmented structure</term><term>Species barrier</term><term>Such viruses</term><term>Surface antigens</term><term>Surface glycoproteins</term><term>Test tube</term><term>Various influenza</term><term>Virology</term><term>Virus</term><term>Virus particles</term><term>Virus strains</term><term>Virus titer</term><term>Water fowls</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Summary: With regard to molecular epidemiology, influenza A viruses belong to the best-studied virus systems. At least two large reservoirs of influenza A viruses have been built up in nature, one in humans and another one in water fowls. The latter one is very heterogenous, consisting of viruses belonging to 13 hemagglutinin (HA) and 9 neuraminidase (NA) subtypes in almost all possible combinations. The segmented structure of the influenza virus genome allows the creation of new influenza strains by reassortment. By replacement of the HA gene of human strains new pandemic viruses can be generated (antigenic shift). The particular structure of the HA enables the human influenza A-viruses to create variants which can escape the immune response of the host (antigenic drift). The nucleoprotein is responsible for keeping those two large reservoirs apart. Mixing of genes of viruses from these two reservoirs seems to happen predominantly by double infection of pigs, which apparently are tolerant for infection by either human or avian influenza viruses. The molecular mechanisms described for influenza viruses can be explained by the particular structure of their genome and their components and cannot be generalized. Each virus has developed its own strategy to multiply and to spread.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country></list><tree><country name="Allemagne"><noRegion><name sortKey="Scholtissek, C" sort="Scholtissek, C" uniqKey="Scholtissek C" first="C." last="Scholtissek">C. Scholtissek</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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